HLA特点
主要组织相容性复合物（Major Histocompatibility Complex，MHC），由一系列紧密连锁的基因座组成。其编码的产物参与抗原呈递，细胞间相互识别以及免疫应答等过程。人的MHC(HLA)位于6号染色体短臂上（6p21.31），由3.6M个碱基组成，是目前已知的人类染色体中基因密度最高，多态性最为丰富的区域。其编码产物在人群中的类型非常丰富。
数据的意义
在肿瘤与病毒的主动性免疫方面，HLA分型与抗原信息，可以为主动性免疫的治疗、机制研究提供重要的靶点信息。
在抗原信息已知的情况下，在实施了HLA检测后，研究者就可以有针对性地完成三种工作：
肿瘤/病毒/自免抗原靶点呈递的HLA类型判断：
可呈递的抗原肽需要HLA类型和蛋白氨基酸序列联合确定，并选择适合的HLA供者抗原呈递细胞，体外激活靶点特异性性激活的T细胞。
肿瘤/病毒/自免抗原特异性T细胞的流式分选与流式检测：
获得HLA信息后，结合靶点信息制造抗原特异性四聚体，使用四聚体分离出T细胞表面抗原特异性TCR。
中国人常见HLA分型
1、HLA-A共有4064种等位基因型蛋白，中国人中3种分型的频率合计超过50%；
2、HLA-B共有4962种等位基因型蛋白，中国人中7种分型的频率合计超过50%；
3、HLA-C共有3831种等位基因型蛋白，中国人中4种分型的频率合计超过50%；
4、HLA-DRB1共有2557种等位基因型蛋白，中国人中5种分型的频率合计超过50%；
4、HLA-DQB1共有1303种等位基因型蛋白，中国人中5种分型的频率合计超过50%；
| Locus | Allele | Freq |
|---|---|---|
| HLA-A | A*11:01 | 20.893% |
| HLA-A | A*24:02 | 15.545% |
| HLA-A | A*02:01 | 12.036% |
| HLA-A | A*02:07 | 8.418% |
| HLA-A | A*33:03 | 8.229% |
| HLA-A | A*30:01 | 5.967% |
| HLA-A | A*02:06 | 5.227% |
| HLA-A | A*01:01 | 3.588% |
| HLA-A | A*02:03 | 3.453% |
| HLA-A | A*31:01 | 3.279% |
| HLA-A | A*03:01 | 2.960% |
| HLA-A | A*26:01 | 2.844% |
| HLA-A | A*11:02 | 1.693% |
| HLA-A | A*32:01 | 1.335% |
| HLA-A | A*68:01 | 0.710% |
| HLA-A | A*29:01 | 0.674% |
| HLA-A | A*02:05 | 0.356% |
| HLA-A | A*02:10 | 0.354% |
| HLA-A | A*24:20 | 0.261% |
| HLA-A | A*23:01 | 0.258% |
| HLA-A | A*03:02 | 0.220% |
| HLA-A | A*24:07 | 0.217% |
| HLA-A | A*33:01 | 0.185% |
| HLA-A | A*24:03 | 0.150% |
| HLA-A | A*69:01 | 0.129% |
| HLA-A | A*11:03 | 0.104% |
| HLA-A | A*24:08 | 0.081% |
| HLA-A | A*30:04 | 0.076% |
| HLA-A | A*24:10 | 0.070% |
| HLA-A | A*29:02 | 0.065% |
| HLA-A | A*66:01 | 0.061% |
| HLA-A | A*68:02 | 0.053% |
| HLA-A | A*02:53N | 0.050% |
| HLA-A | A*34:01 | 0.042% |
| HLA-A | A*24:04 | 0.038% |
| HLA-A | A*74:02 | 0.037% |
| HLA-A | A*02:09 | 0.037% |
| HLA-A | A*30:02 | 0.032% |
| HLA-A | A*26:03 | 0.022% |
| HLA-A | A*25:01 | 0.021% |
| HLA-A | A*02:11 | 0.018% |
| HLA-A | A*30:18 | 0.018% |
| HLA-A | A*26:02 | 0.014% |
| HLA-A | A*01:03 | 0.013% |
| HLA-A | A*02:48 | 0.010% |
| HLA-A | A*26:18 | 0.007% |
| HLA-A | A*26:20 | 0.007% |
| HLA-A | A*68:24 | 0.007% |
| HLA-A | A*24:68 | 0.007% |
| HLA-A | A*11:04 | 0.006% |
| HLA-A | A*02:02 | 0.006% |
| HLA-A | A*02:17 | 0.005% |
| HLA-A | A*24:30 | 0.005% |
| HLA-A | A*02:93 | 0.005% |
| HLA-A | A*02:90 | 0.004% |
| HLA-A | A*74:03 | 0.004% |
| HLA-A | A*02:20 | 0.004% |
| HLA-A | A*24:85 | 0.003% |
| HLA-A | A*31:13 | 0.003% |
| HLA-A | A*74:01 | 0.003% |
| HLA-A | A*02:189 | 0.002% |
| HLA-A | A*74:05 | 0.002% |
| HLA-A | A*02:264 | 0.002% |
| HLA-A | A*24:64 | 0.002% |
| HLA-A | A*29:10 | 0.002% |
| HLA-A | A*03:77 | 0.002% |
| HLA-A | A*68:38 | 0.002% |
| HLA-A | A*33:08 | 0.002% |
| HLA-A | A*11:36 | 0.002% |
| HLA-A | A*24:144 | 0.002% |
| HLA-A | A*36:02 | 0.002% |
| HLA-A | A*02:108 | 0.002% |
| HLA-A | A*26:36 | 0.002% |
| HLA-A | A*31:17 | 0.002% |
| HLA-A | A*24:28 | 0.002% |
| HLA-A | A*24:59 | 0.002% |
| HLA-A | A*24:128 | 0.002% |
| HLA-A | A*02:12 | 0.001% |
| HLA-A | A*26:08 | 0.001% |
| HLA-A | A*02:99 | 0.001% |
| HLA-A | A*02:08 | 0.001% |
| HLA-A | A*24:52 | 0.001% |
| HLA-A | A*02:42 | 0.001% |
| HLA-A | A*24:132N | 0.001% |
| HLA-A | A*11:06 | 0.001% |
| HLA-A | A*24:93 | 0.001% |
| HLA-A | A*01:78 | 0.001% |
| HLA-A | A*68:96 | 0.001% |
| HLA-A | A*11:126 | 0.001% |
| HLA-A | A*11:60 | 0.001% |
| HLA-A | A*34:02 | 0.001% |
| HLA-A | A*24:05 | 0.001% |
| HLA-A | A*11:87 | 0.001% |
| HLA-A | A*02:28 | 0.001% |
| HLA-A | A*74:13 | 0.001% |
| HLA-A | A*31:06 | 0.001% |
| HLA-A | A*02:80 | 0.001% |
| HLA-A | A*02:344 | 0.001% |
| HLA-A | A*02:230 | 0.001% |
| HLA-A | A*11:56 | 0.001% |
| HLA-A | A*02:79 | 0.001% |
| HLA-A | A*24:13 | 0.001% |
| HLA-A | A*24:21 | 0.001% |
| HLA-A | A*24:17 | 0.001% |
| HLA-A | A*23:26 | 0.001% |
| HLA-A | A*23:20 | 0.001% |
| HLA-A | A*02:251 | 0.001% |
| HLA-A | A*24:98 | 0.001% |
| HLA-A | A*02:121 | 0.001% |
| HLA-A | A*02:249 | 0.001% |
| HLA-A | A*30:20 | 0.001% |
| HLA-A | A*11:77 | 0.001% |
| HLA-A | A*11:88 | 0.001% |
| HLA-A | A*02:269 | 0.001% |
| HLA-A | A*24:150 | 0.001% |
| HLA-A | A*32:54 | 0.001% |
| HLA-A | A*11:12 | 0.001% |
| HLA-A | A*11:69N | 0.001% |
| HLA-A | A*24:152 | 0.000% |
| HLA-A | A*11:32 | 0.000% |
| HLA-A | A*11:61 | 0.000% |
| HLA-A | A*33:10 | 0.000% |
| HLA-A | A*02:259 | 0.000% |
| HLA-A | A*33:30 | 0.000% |
| HLA-A | A*02:256 | 0.000% |
| HLA-A | A*26:14 | 0.000% |
| HLA-A | A*03:05 | 0.000% |
| HLA-A | A*02:36 | 0.000% |
| HLA-A | A*24:33 | 0.000% |
| HLA-A | A*11:14 | 0.000% |
| HLA-A | A*03:12 | 0.000% |
| HLA-A | A*11:19 | 0.000% |
| HLA-A | A*30:38 | 0.000% |
| HLA-A | A*26:35 | 0.000% |
| HLA-A | A*24:91 | 0.000% |
| HLA-A | A*24:06 | 0.000% |
| HLA-A | A*31:33 | 0.000% |
| HLA-A | A*02:446 | 0.000% |
| HLA-A | A*26:17 | 0.000% |
| HLA-A | A*02:419 | 0.000% |
| HLA-A | A*31:32 | 0.000% |
| HLA-A | A*24:112 | 0.000% |
| HLA-A | A*02:24 | 0.000% |
| HLA-A | A*26:50 | 0.000% |
| HLA-A | A*02:293Q | 0.000% |
| HLA-A | A*31:30 | 0.000% |
| HLA-A | A*03:20 | 0.000% |
| HLA-A | A*02:478 | 0.000% |
| HLA-A | A*11:163 | 0.000% |
| HLA-A | A*24:225 | 0.000% |
| HLA-A | A*11:100 | 0.000% |
| HLA-A | A*11:27 | 0.000% |
| HLA-A | A*24:141 | 0.000% |
| HLA-A | A*26:09 | 0.000% |
| HLA-A | A*02:426 | 0.000% |
| HLA-A »ã×Ü | 100.000% | |
| HLA-B | B*46:01 | 10.257% |
| HLA-B | B*40:01 | 9.549% |
| HLA-B | B*13:02 | 6.322% |
| HLA-B | B*58:01 | 6.149% |
| HLA-B | B*51:01 | 5.619% |
| HLA-B | B*13:01 | 5.013% |
| HLA-B | B*15:01 | 4.784% |
| HLA-B | B*15:02 | 3.554% |
| HLA-B | B*40:06 | 3.232% |
| HLA-B | B*54:01 | 3.131% |
| HLA-B | B*52:01 | 2.991% |
| HLA-B | B*44:03 | 2.766% |
| HLA-B | B*38:02 | 2.594% |
| HLA-B | B*55:02 | 2.472% |
| HLA-B | B*48:01 | 2.469% |
| HLA-B | B*35:01 | 2.430% |
| HLA-B | B*07:02 | 2.123% |
| HLA-B | B*40:02 | 1.868% |
| HLA-B | B*15:11 | 1.849% |
| HLA-B | B*39:01 | 1.774% |
| HLA-B | B*37:01 | 1.403% |
| HLA-B | B*15:18 | 1.368% |
| HLA-B | B*57:01 | 1.171% |
| HLA-B | B*35:03 | 1.120% |
| HLA-B | B*51:02 | 1.053% |
| HLA-B | B*27:04 | 0.911% |
| HLA-B | B*08:01 | 0.911% |
| HLA-B | B*44:02 | 0.863% |
| HLA-B | B*15:27 | 0.856% |
| HLA-B | B*27:05 | 0.726% |
| HLA-B | B*67:01 | 0.720% |
| HLA-B | B*50:01 | 0.690% |
| HLA-B | B*15:25 | 0.556% |
| HLA-B | B*07:05 | 0.533% |
| HLA-B | B*38:01 | 0.508% |
| HLA-B | B*56:01 | 0.484% |
| HLA-B | B*18:01 | 0.360% |
| HLA-B | B*15:07 | 0.324% |
| HLA-B | B*14:02 | 0.297% |
| HLA-B | B*35:05 | 0.270% |
| HLA-B | B*15:12 | 0.231% |
| HLA-B | B*35:02 | 0.220% |
| HLA-B | B*40:03 | 0.219% |
| HLA-B | B*15:32 | 0.215% |
| HLA-B | B*15:17 | 0.204% |
| HLA-B | B*15:05 | 0.181% |
| HLA-B | B*49:01 | 0.175% |
| HLA-B | B*39:05 | 0.174% |
| HLA-B | B*48:03 | 0.155% |
| HLA-B | B*27:07 | 0.151% |
| HLA-B | B*35:08 | 0.145% |
| HLA-B | B*45:01 | 0.112% |
| HLA-B | B*41:01 | 0.109% |
| HLA-B | B*55:01 | 0.100% |
| HLA-B | B*59:01 | 0.095% |
| HLA-B | B*15:58 | 0.085% |
| HLA-B | B*56:04 | 0.077% |
| HLA-B | B*81:02 | 0.071% |
| HLA-B | B*18:02 | 0.055% |
| HLA-B | B*27:06 | 0.054% |
| HLA-B | B*15:13 | 0.054% |
| HLA-B | B*14:01 | 0.051% |
| HLA-B | B*55:04 | 0.050% |
| HLA-B | B*15:46 | 0.046% |
| HLA-B | B*07:06 | 0.045% |
| HLA-B | B*40:40 | 0.045% |
| HLA-B | B*51:08 | 0.040% |
| HLA-B | B*56:03 | 0.038% |
| HLA-B | B*55:12 | 0.035% |
| HLA-B | B*53:01 | 0.034% |
| HLA-B | B*51:07 | 0.033% |
| HLA-B | B*15:21 | 0.033% |
| HLA-B | B*39:09 | 0.032% |
| HLA-B | B*27:24 | 0.028% |
| HLA-B | B*15:19 | 0.027% |
| HLA-B | B*15:03 | 0.027% |
| HLA-B | B*15:35 | 0.027% |
| HLA-B | B*55:07 | 0.026% |
| HLA-B | B*41:02 | 0.025% |
| HLA-B | B*47:01 | 0.021% |
| HLA-B | B*27:02 | 0.021% |
| HLA-B | B*40:229 | 0.019% |
| HLA-B | B*15:08 | 0.019% |
| HLA-B | B*15:29 | 0.015% |
| HLA-B | B*39:15 | 0.014% |
| HLA-B | B*42:01 | 0.012% |
| HLA-B | B*73:01 | 0.012% |
| HLA-B | B*39:24 | 0.011% |
| HLA-B | B*51:36 | 0.011% |
| HLA-B | B*40:55 | 0.011% |
| HLA-B | B*40:78 | 0.010% |
| HLA-B | B*27:25 | 0.009% |
| HLA-B | B*51:06 | 0.009% |
| HLA-B | B*15:220 | 0.009% |
| HLA-B | B*15:10 | 0.008% |
| HLA-B | B*15:38 | 0.008% |
| HLA-B | B*27:03 | 0.008% |
| HLA-B | B*44:05 | 0.007% |
| HLA-B | B*40:97 | 0.007% |
| HLA-B | B*07:10 | 0.006% |
| HLA-B | B*39:06 | 0.006% |
| HLA-B | B*15:68 | 0.006% |
| HLA-B | B*56:10 | 0.006% |
| HLA-B | B*27:15 | 0.006% |
| HLA-B | B*27:36 | 0.005% |
| HLA-B | B*57:03 | 0.005% |
| HLA-B | B*40:150 | 0.005% |
| HLA-B | B*54:17 | 0.005% |
| HLA-B | B*15:198 | 0.005% |
| HLA-B | B*39:31 | 0.005% |
| HLA-B | B*81:01 | 0.005% |
| HLA-B | B*42:02 | 0.004% |
| HLA-B | B*15:178 | 0.004% |
| HLA-B | B*37:04 | 0.004% |
| HLA-B | B*35:11 | 0.003% |
| HLA-B | B*40:84 | 0.003% |
| HLA-B | B*44:27 | 0.003% |
| HLA-B | B*51:09 | 0.003% |
| HLA-B | B*51:22 | 0.003% |
| HLA-B | B*48:04 | 0.002% |
| HLA-B | B*57:02 | 0.002% |
| HLA-B | B*40:50 | 0.002% |
| HLA-B | B*40:11 | 0.002% |
| HLA-B | B*55:21 | 0.002% |
| HLA-B | B*27:14 | 0.002% |
| HLA-B | B*56:14 | 0.002% |
| HLA-B | B*15:09 | 0.002% |
| HLA-B | B*51:21 | 0.002% |
| HLA-B | B*38:15 | 0.002% |
| HLA-B | B*27:69 | 0.002% |
| HLA-B | B*51:39 | 0.002% |
| HLA-B | B*35:42 | 0.002% |
| HLA-B | B*35:04 | 0.001% |
| HLA-B | B*15:39 | 0.001% |
| HLA-B | B*51:34 | 0.001% |
| HLA-B | B*18:03 | 0.001% |
| HLA-B | B*40:48 | 0.001% |
| HLA-B | B*15:86 | 0.001% |
| HLA-B | B*55:16 | 0.001% |
| HLA-B | B*13:16 | 0.001% |
| HLA-B | B*57:29 | 0.001% |
| HLA-B | B*39:04 | 0.001% |
| HLA-B | B*35:30 | 0.001% |
| HLA-B | B*15:134 | 0.001% |
| HLA-B | B*40:10 | 0.001% |
| HLA-B | B*40:141 | 0.001% |
| HLA-B | B*15:152 | 0.001% |
| HLA-B | B*40:43 | 0.001% |
| HLA-B | B*07:48 | 0.001% |
| HLA-B | B*52:04 | 0.001% |
| HLA-B | B*55:30 | 0.001% |
| HLA-B | B*56:21 | 0.001% |
| HLA-B | B*56:18 | 0.001% |
| HLA-B | B*40:122 | 0.001% |
| HLA-B | B*39:36 | 0.001% |
| HLA-B | B*35:37 | 0.001% |
| HLA-B | B*46:09 | 0.001% |
| HLA-B | B*35:64 | 0.001% |
| HLA-B | B*52:11 | 0.001% |
| HLA-B | B*15:88 | 0.001% |
| HLA-B | B*54:16 | 0.001% |
| HLA-B | B*07:116 | 0.001% |
| HLA-B | B*46:19 | 0.001% |
| HLA-B | B*15:201 | 0.001% |
| HLA-B | B*15:78 | 0.000% |
| HLA-B | B*56:09 | 0.000% |
| HLA-B | B*55:50 | 0.000% |
| HLA-B | B*40:125 | 0.000% |
| HLA-B | B*40:81 | 0.000% |
| HLA-B | B*78:02 | 0.000% |
| HLA-B | B*15:65 | 0.000% |
| HLA-B | B*39:10 | 0.000% |
| HLA-B | B*39:38Q | 0.000% |
| HLA-B | B*40:70 | 0.000% |
| HLA-B | B*40:140 | 0.000% |
| HLA-B | B*58:12 | 0.000% |
| HLA-B | B*13:38 | 0.000% |
| HLA-B | B*51:59 | 0.000% |
| HLA-B | B*07:08 | 0.000% |
| HLA-B | B*15:192 | 0.000% |
| HLA-B | B*07:81 | 0.000% |
| HLA-B | B*40:49 | 0.000% |
| HLA-B | B*44:29 | 0.000% |
| HLA-B | B*67:03 | 0.000% |
| HLA-B | B*15:227 | 0.000% |
| HLA-B | B*44:118 | 0.000% |
| HLA-B | B*40:268 | 0.000% |
| HLA-B | B*40:153 | 0.000% |
| HLA-B | B*40:75 | 0.000% |
| HLA-B | B*55:34 | 0.000% |
| HLA-B | B*15:15 | 0.000% |
| HLA-B | B*15:16 | 0.000% |
| HLA-B | B*78:01 | 0.000% |
| HLA-B | B*15:30 | 0.000% |
| HLA-B | B*07:18 | 0.000% |
| HLA-B | B*39:58 | 0.000% |
| HLA-B | B*27:61 | 0.000% |
| HLA-B | B*35:28 | 0.000% |
| HLA-B | B*40:207 | 0.000% |
| HLA-B | B*37:02 | 0.000% |
| HLA-B | B*27:01 | 0.000% |
| HLA-B | B*46:18 | 0.000% |
| HLA-B | B*55:26 | 0.000% |
| HLA-B | B*07:91 | 0.000% |
| HLA-B | B*55:43 | 0.000% |
| HLA-B | B*48:06 | 0.000% |
| HLA-B | B*58:58 | 0.000% |
| HLA-B | B*56:27 | 0.000% |
| HLA-B | B*40:25 | 0.000% |
| HLA-B | B*51:130 | 0.000% |
| HLA-B | B*51:05 | 0.000% |
| HLA-B | B*52:20 | 0.000% |
| HLA-B | B*40:255 | 0.000% |
| HLA-B | B*35:29 | 0.000% |
| HLA-B | B*51:04 | 0.000% |
| HLA-B | B*35:189 | 0.000% |
| HLA-B | B*40:69 | 0.000% |
| HLA-B »ã×Ü | 100.000% | |
| HLA-C | C*01:02 | 15.889% |
| HLA-C | C*07:02 | 15.200% |
| HLA-C | C*03:04 | 9.878% |
| HLA-C | C*06:02 | 8.896% |
| HLA-C | C*08:01 | 8.520% |
| HLA-C | C*03:03 | 6.962% |
| HLA-C | C*03:02 | 5.950% |
| HLA-C | C*04:01 | 5.790% |
| HLA-C | C*14:02 | 4.274% |
| HLA-C | C*15:02 | 3.337% |
| HLA-C | C*12:02 | 3.139% |
| HLA-C | C*12:03 | 1.914% |
| HLA-C | C*14:03 | 1.031% |
| HLA-C | C*04:03 | 1.015% |
| HLA-C | C*08:22 | 0.870% |
| HLA-C | C*07:04 | 0.868% |
| HLA-C | C*05:01 | 0.849% |
| HLA-C | C*07:06 | 0.800% |
| HLA-C | C*08:03 | 0.775% |
| HLA-C | C*15:05 | 0.707% |
| HLA-C | C*02:02 | 0.694% |
| HLA-C | C*01:03 | 0.625% |
| HLA-C | C*07:01 | 0.572% |
| HLA-C | C*08:02 | 0.299% |
| HLA-C | C*04:82 | 0.236% |
| HLA-C | C*16:02 | 0.202% |
| HLA-C | C*17:01 | 0.101% |
| HLA-C | C*01:06 | 0.084% |
| HLA-C | C*16:04 | 0.077% |
| HLA-C | C*07:66 | 0.075% |
| HLA-C | C*15:04 | 0.037% |
| HLA-C | C*04:06 | 0.027% |
| HLA-C | C*07:18 | 0.025% |
| HLA-C | C*03:17 | 0.024% |
| HLA-C | C*17:03 | 0.022% |
| HLA-C | C*01:08 | 0.019% |
| HLA-C | C*15:13 | 0.016% |
| HLA-C | C*03:56 | 0.015% |
| HLA-C | C*07:154 | 0.014% |
| HLA-C | C*15:11 | 0.014% |
| HLA-C | C*07:43 | 0.012% |
| HLA-C | C*07:63 | 0.010% |
| HLA-C | C*08:06 | 0.009% |
| HLA-C | C*03:36 | 0.006% |
| HLA-C | C*15:26 | 0.006% |
| HLA-C | C*03:100 | 0.006% |
| HLA-C | C*07:67 | 0.005% |
| HLA-C | C*16:01 | 0.005% |
| HLA-C | C*08:41 | 0.005% |
| HLA-C | C*12:05 | 0.005% |
| HLA-C | C*07:27 | 0.005% |
| HLA-C | C*04:69 | 0.004% |
| HLA-C | C*03:38 | 0.003% |
| HLA-C | C*08:24 | 0.003% |
| HLA-C | C*08:44 | 0.003% |
| HLA-C | C*15:06 | 0.003% |
| HLA-C | C*14:25 | 0.002% |
| HLA-C | C*04:130 | 0.002% |
| HLA-C | C*07:19 | 0.002% |
| HLA-C | C*07:26 | 0.002% |
| HLA-C | C*03:85 | 0.002% |
| HLA-C | C*15:29 | 0.002% |
| HLA-C | C*03:21 | 0.002% |
| HLA-C | C*15:17 | 0.002% |
| HLA-C | C*04:70 | 0.002% |
| HLA-C | C*06:103 | 0.002% |
| HLA-C | C*18:02 | 0.002% |
| HLA-C | C*04:08 | 0.002% |
| HLA-C | C*01:85 | 0.001% |
| HLA-C | C*03:28 | 0.001% |
| HLA-C | C*07:56 | 0.001% |
| HLA-C | C*03:39 | 0.001% |
| HLA-C | C*08:27 | 0.001% |
| HLA-C | C*01:17 | 0.001% |
| HLA-C | C*17:02 | 0.001% |
| HLA-C | C*07:159 | 0.001% |
| HLA-C | C*15:12 | 0.001% |
| HLA-C | C*15:21 | 0.001% |
| HLA-C | C*07:16 | 0.001% |
| HLA-C | C*03:40 | 0.001% |
| HLA-C | C*03:76 | 0.001% |
| HLA-C | C*14:23 | 0.001% |
| HLA-C | C*04:81 | 0.001% |
| HLA-C | C*03:198 | 0.001% |
| HLA-C | C*08:21 | 0.001% |
| HLA-C | C*14:24 | 0.001% |
| HLA-C | C*12:18 | 0.001% |
| HLA-C | C*02:10 | 0.001% |
| HLA-C | C*07:51 | 0.001% |
| HLA-C | C*06:06 | 0.001% |
| HLA-C | C*01:22 | 0.001% |
| HLA-C | C*01:30 | 0.001% |
| HLA-C | C*06:04 | 0.001% |
| HLA-C | C*03:211 | 0.001% |
| HLA-C | C*08:86 | 0.001% |
| HLA-C | C*14:12 | 0.001% |
| HLA-C | C*01:58 | 0.001% |
| HLA-C | C*03:41 | 0.001% |
| HLA-C | C*15:07 | 0.001% |
| HLA-C | C*01:10 | 0.001% |
| HLA-C | C*07:169 | 0.001% |
| HLA-C | C*01:50 | 0.001% |
| HLA-C | C*03:16 | 0.001% |
| HLA-C | C*03:35 | 0.001% |
| HLA-C | C*08:10 | 0.001% |
| HLA-C | C*03:64 | 0.001% |
| HLA-C | C*12:04 | 0.001% |
| HLA-C | C*03:32 | 0.001% |
| HLA-C | C*01:44 | 0.001% |
| HLA-C | C*03:69 | 0.001% |
| HLA-C | C*03:48 | 0.001% |
| HLA-C | C*03:43 | 0.001% |
| HLA-C | C*14:29 | 0.001% |
| HLA-C | C*07:172 | 0.000% |
| HLA-C | C*06:104 | 0.000% |
| HLA-C | C*03:07 | 0.000% |
| HLA-C | C*03:107 | 0.000% |
| HLA-C | C*15:09 | 0.000% |
| HLA-C | C*12:09 | 0.000% |
| HLA-C | C*01:40 | 0.000% |
| HLA-C | C*06:106 | 0.000% |
| HLA-C | C*03:210 | 0.000% |
| HLA-C | C*03:46 | 0.000% |
| HLA-C | C*06:73 | 0.000% |
| HLA-C | C*03:204 | 0.000% |
| HLA-C »ã×Ü | 100.000% | |
| HLA-DQB1 | DQB1*03:01 | 21.068% |
| HLA-DQB1 | DQB1*03:03 | 15.907% |
| HLA-DQB1 | DQB1*06:01 | 10.248% |
| HLA-DQB1 | DQB1*06:02 | 7.571% |
| HLA-DQB1 | DQB1*02:02 | 7.533% |
| HLA-DQB1 | DQB1*05:02 | 7.366% |
| HLA-DQB1 | DQB1*03:02 | 5.739% |
| HLA-DQB1 | DQB1*02:01 | 4.968% |
| HLA-DQB1 | DQB1*05:01 | 4.639% |
| HLA-DQB1 | DQB1*04:01 | 4.509% |
| HLA-DQB1 | DQB1*05:03 | 4.196% |
| HLA-DQB1 | DQB1*06:09 | 1.693% |
| HLA-DQB1 | DQB1*06:03 | 1.468% |
| HLA-DQB1 | DQB1*06:04 | 1.427% |
| HLA-DQB1 | DQB1*04:02 | 1.255% |
| HLA-DQB1 | DQB1*06:10 | 0.101% |
| HLA-DQB1 | DQB1*03:05 | 0.092% |
| HLA-DQB1 | DQB1*03:13 | 0.074% |
| HLA-DQB1 | DQB1*03:04 | 0.031% |
| HLA-DQB1 | DQB1*05:10 | 0.031% |
| HLA-DQB1 | DQB1*05:04 | 0.017% |
| HLA-DQB1 | DQB1*06:41 | 0.015% |
| HLA-DQB1 | DQB1*03:17 | 0.012% |
| HLA-DQB1 | DQB1*06:07 | 0.010% |
| HLA-DQB1 | DQB1*03:29 | 0.003% |
| HLA-DQB1 | DQB1*03:22 | 0.003% |
| HLA-DQB1 | DQB1*03:38 | 0.003% |
| HLA-DQB1 | DQB1*03:27 | 0.002% |
| HLA-DQB1 | DQB1*05:08 | 0.002% |
| HLA-DQB1 | DQB1*03:34 | 0.001% |
| HLA-DQB1 | DQB1*06:11 | 0.001% |
| HLA-DQB1 | DQB1*06:103 | 0.001% |
| HLA-DQB1 | DQB1*03:14 | 0.001% |
| HLA-DQB1 | DQB1*06:84 | 0.001% |
| HLA-DQB1 | DQB1*02:12 | 0.001% |
| HLA-DQB1 | DQB1*03:50 | 0.001% |
| HLA-DQB1 | DQB1*02:03 | 0.001% |
| HLA-DQB1 | DQB1*03:26 | 0.001% |
| HLA-DQB1 | DQB1*04:08 | 0.001% |
| HLA-DQB1 | DQB1*03:19 | 0.001% |
| HLA-DQB1 | DQB1*03:24 | 0.001% |
| HLA-DQB1 | DQB1*03:30 | 0.001% |
| HLA-DQB1 | DQB1*05:18 | 0.001% |
| HLA-DQB1 | DQB1*06:05 | 0.001% |
| HLA-DQB1 | DQB1*03:32 | 0.001% |
| HLA-DQB1 | DQB1*05:05 | 0.000% |
| HLA-DQB1 | DQB1*06:107 | 0.000% |
| HLA-DQB1 | DQB1*03:44 | 0.000% |
| HLA-DQB1 | DQB1*03:93 | 0.000% |
| HLA-DQB1 »ã×Ü | 100.000% | |
| HLA-DRB1 | DRB1*09:01 | 14.787% |
| HLA-DRB1 | DRB1*15:01 | 11.584% |
| HLA-DRB1 | DRB1*07:01 | 9.660% |
| HLA-DRB1 | DRB1*12:02 | 8.706% |
| HLA-DRB1 | DRB1*08:03 | 6.312% |
| HLA-DRB1 | DRB1*11:01 | 5.630% |
| HLA-DRB1 | DRB1*03:01 | 5.102% |
| HLA-DRB1 | DRB1*04:05 | 4.819% |
| HLA-DRB1 | DRB1*13:02 | 3.340% |
| HLA-DRB1 | DRB1*15:02 | 3.133% |
| HLA-DRB1 | DRB1*16:02 | 3.056% |
| HLA-DRB1 | DRB1*04:06 | 2.570% |
| HLA-DRB1 | DRB1*12:01 | 2.412% |
| HLA-DRB1 | DRB1*14:54 | 2.343% |
| HLA-DRB1 | DRB1*14:05 | 2.201% |
| HLA-DRB1 | DRB1*01:01 | 2.071% |
| HLA-DRB1 | DRB1*10:01 | 1.588% |
| HLA-DRB1 | DRB1*04:03 | 1.557% |
| HLA-DRB1 | DRB1*13:01 | 1.456% |
| HLA-DRB1 | DRB1*04:01 | 0.997% |
| HLA-DRB1 | DRB1*04:04 | 0.740% |
| HLA-DRB1 | DRB1*13:12 | 0.729% |
| HLA-DRB1 | DRB1*08:02 | 0.675% |
| HLA-DRB1 | DRB1*14:04 | 0.664% |
| HLA-DRB1 | DRB1*11:04 | 0.604% |
| HLA-DRB1 | DRB1*14:03 | 0.528% |
| HLA-DRB1 | DRB1*04:10 | 0.288% |
| HLA-DRB1 | DRB1*01:02 | 0.265% |
| HLA-DRB1 | DRB1*14:07 | 0.237% |
| HLA-DRB1 | DRB1*15:04 | 0.237% |
| HLA-DRB1 | DRB1*12:10 | 0.235% |
| HLA-DRB1 | DRB1*04:07 | 0.207% |
| HLA-DRB1 | DRB1*04:02 | 0.174% |
| HLA-DRB1 | DRB1*08:09 | 0.167% |
| HLA-DRB1 | DRB1*04:08 | 0.129% |
| HLA-DRB1 | DRB1*11:06 | 0.100% |
| HLA-DRB1 | DRB1*14:18 | 0.090% |
| HLA-DRB1 | DRB1*16:01 | 0.070% |
| HLA-DRB1 | DRB1*13:07 | 0.054% |
| HLA-DRB1 | DRB1*08:01 | 0.050% |
| HLA-DRB1 | DRB1*13:03 | 0.050% |
| HLA-DRB1 | DRB1*14:01 | 0.039% |
| HLA-DRB1 | DRB1*14:12 | 0.039% |
| HLA-DRB1 | DRB1*11:03 | 0.037% |
| HLA-DRB1 | DRB1*08:04 | 0.036% |
| HLA-DRB1 | DRB1*14:10 | 0.029% |
| HLA-DRB1 | DRB1*14:02 | 0.025% |
| HLA-DRB1 | DRB1*14:25 | 0.017% |
| HLA-DRB1 | DRB1*14:06 | 0.013% |
| HLA-DRB1 | DRB1*15:06 | 0.011% |
| HLA-DRB1 | DRB1*11:28 | 0.011% |
| HLA-DRB1 | DRB1*13:50 | 0.009% |
| HLA-DRB1 | DRB1*12:08 | 0.008% |
| HLA-DRB1 | DRB1*13:05 | 0.008% |
| HLA-DRB1 | DRB1*11:11 | 0.006% |
| HLA-DRB1 | DRB1*12:05 | 0.005% |
| HLA-DRB1 | DRB1*03:27 | 0.005% |
| HLA-DRB1 | DRB1*11:129 | 0.005% |
| HLA-DRB1 | DRB1*09:04 | 0.004% |
| HLA-DRB1 | DRB1*13:19 | 0.004% |
| HLA-DRB1 | DRB1*14:22 | 0.004% |
| HLA-DRB1 | DRB1*04:11 | 0.004% |
| HLA-DRB1 | DRB1*14:11 | 0.004% |
| HLA-DRB1 | DRB1*15:03 | 0.003% |
| HLA-DRB1 | DRB1*07:13 | 0.003% |
| HLA-DRB1 | DRB1*14:44 | 0.003% |
| HLA-DRB1 | DRB1*14:49 | 0.002% |
| HLA-DRB1 | DRB1*14:61 | 0.002% |
| HLA-DRB1 | DRB1*11:19 | 0.002% |
| HLA-DRB1 | DRB1*15:11 | 0.002% |
| HLA-DRB1 | DRB1*11:08 | 0.001% |
| HLA-DRB1 | DRB1*14:33 | 0.001% |
| HLA-DRB1 | DRB1*11:20 | 0.001% |
| HLA-DRB1 | DRB1*08:19 | 0.001% |
| HLA-DRB1 | DRB1*13:13 | 0.001% |
| HLA-DRB1 | DRB1*14:141 | 0.001% |
| HLA-DRB1 | DRB1*11:101 | 0.001% |
| HLA-DRB1 | DRB1*08:36 | 0.001% |
| HLA-DRB1 | DRB1*01:14 | 0.001% |
| HLA-DRB1 | DRB1*08:14 | 0.001% |
| HLA-DRB1 | DRB1*09:10 | 0.001% |
| HLA-DRB1 | DRB1*13:14 | 0.001% |
| HLA-DRB1 | DRB1*16:09 | 0.001% |
| HLA-DRB1 | DRB1*08:12 | 0.001% |
| HLA-DRB1 | DRB1*11:39 | 0.001% |
| HLA-DRB1 | DRB1*11:37 | 0.001% |
| HLA-DRB1 | DRB1*11:106 | 0.001% |
| HLA-DRB1 | DRB1*08:30 | 0.001% |
| HLA-DRB1 | DRB1*11:02 | 0.001% |
| HLA-DRB1 | DRB1*12:19 | 0.001% |
| HLA-DRB1 | DRB1*04:13 | 0.001% |
| HLA-DRB1 | DRB1*12:28 | 0.001% |
| HLA-DRB1 | DRB1*11:75 | 0.001% |
| HLA-DRB1 | DRB1*13:08 | 0.001% |
| HLA-DRB1 | DRB1*15:07 | 0.001% |
| HLA-DRB1 | DRB1*11:54 | 0.001% |
| HLA-DRB1 | DRB1*11:57 | 0.001% |
| HLA-DRB1 | DRB1*12:18 | 0.001% |
| HLA-DRB1 | DRB1*12:27 | 0.001% |
| HLA-DRB1 | DRB1*04:17 | 0.001% |
| HLA-DRB1 | DRB1*11:15 | 0.001% |
| HLA-DRB1 | DRB1*13:118 | 0.001% |
| HLA-DRB1 | DRB1*08:32 | 0.001% |
| HLA-DRB1 | DRB1*03:05 | 0.001% |
| HLA-DRB1 | DRB1*11:23 | 0.001% |
| HLA-DRB1 | DRB1*11:29 | 0.001% |
| HLA-DRB1 | DRB1*07:11 | 0.000% |
| HLA-DRB1 | DRB1*09:06 | 0.000% |
| HLA-DRB1 | DRB1*04:38 | 0.000% |
| HLA-DRB1 | DRB1*04:59 | 0.000% |
| HLA-DRB1 | DRB1*16:10 | 0.000% |
| HLA-DRB1 | DRB1*08:35 | 0.000% |
| HLA-DRB1 | DRB1*08:18 | 0.000% |
| HLA-DRB1 | DRB1*03:06 | 0.000% |
| HLA-DRB1 | DRB1*11:27 | 0.000% |
| HLA-DRB1 | DRB1*16:05 | 0.000% |
| HLA-DRB1 | DRB1*12:14 | 0.000% |
| HLA-DRB1 | DRB1*03:11 | 0.000% |
| HLA-DRB1 | DRB1*11:12 | 0.000% |
| HLA-DRB1 | DRB1*12:16 | 0.000% |
| HLA-DRB1 | DRB1*12:20 | 0.000% |
| HLA-DRB1 | DRB1*08:41 | 0.000% |
| HLA-DRB1 | DRB1*04:93 | 0.000% |
| HLA-DRB1 | DRB1*15:49 | 0.000% |
| HLA-DRB1 | DRB1*09:07 | 0.000% |
| HLA-DRB1 | DRB1*11:111 | 0.000% |
| HLA-DRB1 | DRB1*15:05 | 0.000% |
| HLA-DRB1 | DRB1*14:15 | 0.000% |
| HLA-DRB1 | DRB1*03:08 | 0.000% |
| HLA-DRB1 | DRB1*04:88 | 0.000% |
| HLA-DRB1 »ã×Ü | 100.000% |
参考文献
Common and well-documented (CWD) alleles of human leukocyte antigen-A, -B, -C, -DRB1, and -DQB1 loci for the Chinese Han population do not quite correlate with the ASHI CWD alleles.
He J, Li Y, Bao X, Qiu Q, Yuan X, Xu C, Shen J, Hou J.
Hum Immunol. 2012 Jan;73(1):61-6. doi: 10.1016/j.humimm.2011.06.005. Epub 2011 Jun 15.
PMID: 21712058[Identification and analysis of the rare HLA-A/B/DRB1 allele genes of 10165 bone marrow registry donors in Shaanxi region].
Liu ML, Qi J, Wang XF, Liu S, Wang TJ, Chen LP.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Dec;21(6):1602-5. doi: 10.7534/j.issn.1009-2137.2013.06.044.
PMID: 24370056 Chinese.
The CWD allele catalog in China.
Cano P, Mack SJ, Fernández-Viña M.
Hum Immunol. 2012 Jan;73(1):60. doi: 10.1016/j.humimm.2011.08.010. Epub 2011 Aug 30.
