随着肿瘤新生抗原、肿瘤mRNA疫苗、TCR-T疗法等肿瘤免疫方向普及，很多用户询问各种肿瘤的HLA选择策略。为了回答好这个问题，我们分析了83篇肿瘤免疫研究的高引用文献，列出了7种肿瘤相关的热点HLA类型。这些HLA及其呈递的抗原肽经过T细胞活化、四聚体流式定量检测等验证。
实体瘤新抗原HLA热点类型
从上图可见，A0201、A2402、A1101、A0206、C0304共5种HLA涉及3种以上肿瘤类型，这可能是由于这些HLA是人群分布的主要HLA类型所致(参考中国人HLA类型分布特征)。
不同肿瘤文献名称与HLA类型对应表 (均有现货出售)
下表可以在搜索框中输入疾病名称、感兴趣关键词查询相关信息：
| Allele | TCGA_Freq | TCGA Rank | Chinese_Freq | Chinese Rank |
|---|---|---|---|---|
| HLA-A*02:01 | 8.15% | 1 | 12.04% | 5 |
| HLA-C*07:01 | 4.84% | 2 | 0.57% | 69 |
| HLA-A*01:01 | 4.58% | 3 | 3.59% | 24 |
| HLA-C*07:02 | 4.31% | 4 | 15.20% | 4 |
| HLA-A*03:01 | 4.15% | 5 | 2.96% | 33 |
| HLA-C*04:01 | 3.95% | 6 | 5.79% | 18 |
| HLA-B*07:02 | 3.71% | 7 | 2.12% | 40 |
| HLA-A*24:02 | 3.22% | 8 | 15.55% | 3 |
| HLA-B*08:01 | 3.02% | 9 | 0.91% | 55 |
| HLA-C*06:02 | 2.85% | 10 | 8.90% | 9 |
| HLA-C*05:01 | 2.75% | 11 | 0.85% | 58 |
| HLA-B*44:02 | 2.63% | 12 | 0.86% | 57 |
| HLA-B*35:01 | 2.31% | 13 | 2.43% | 39 |
| HLA-C*03:04 | 2.12% | 14 | 9.88% | 7 |
| HLA-C*12:03 | 1.95% | 15 | 1.91% | 41 |
| HLA-B*51:01 | 1.79% | 16 | 5.62% | 19 |
| HLA-A*11:01 | 1.72% | 17 | 20.89% | 1 |
| HLA-B*15:01 | 1.69% | 18 | 4.78% | 22 |
| HLA-B*18:01 | 1.56% | 19 | 0.36% | 74 |
| HLA-C*03:03 | 1.53% | 20 | 6.96% | 13 |
| HLA-B*44:03 | 1.51% | 21 | 2.77% | 35 |
| HLA-B*40:01 | 1.44% | 22 | 9.55% | 8 |
| HLA-A*68:01 | 1.41% | 23 | 0.71% | 63 |
| HLA-A*31:01 | 1.36% | 24 | 3.28% | 28 |
| HLA-C*02:02 | 1.35% | 25 | 0.69% | 65 |
| HLA-C*15:02 | 1.14% | 26 | 3.34% | 27 |
| HLA-C*01:02 | 1.12% | 27 | 15.89% | 2 |
| HLA-C*16:01 | 1.12% | 28 | 0.01% | 157 |
| HLA-B*57:01 | 0.98% | 29 | 1.17% | 49 |
| HLA-A*26:01 | 0.88% | 30 | 2.84% | 34 |
| HLA-A*32:01 | 0.87% | 31 | 1.34% | 48 |
| HLA-C*08:02 | 0.87% | 32 | 0.30% | 78 |
| HLA-B*13:02 | 0.85% | 33 | 6.32% | 14 |
| HLA-A*25:01 | 0.84% | 34 | 0.02% | 136 |
| HLA-B*27:05 | 0.82% | 35 | 0.73% | 61 |
| HLA-A*23:01 | 0.76% | 36 | 0.26% | 82 |
| HLA-A*29:02 | 0.73% | 37 | 0.07% | 110 |
| HLA-B*40:02 | 0.69% | 38 | 1.87% | 42 |
| HLA-B*37:01 | 0.67% | 39 | 1.40% | 46 |
| HLA-B*14:02 | 0.67% | 40 | 0.30% | 79 |
| HLA-B*39:06 | 0.63% | 41 | 0.01% | 153 |
| HLA-B*38:01 | 0.62% | 42 | 0.51% | 72 |
| HLA-C*07:04 | 0.53% | 43 | 0.87% | 56 |
| HLA-A*30:01 | 0.50% | 44 | 5.97% | 16 |
| HLA-B*49:01 | 0.47% | 45 | 0.18% | 92 |
| HLA-B*35:03 | 0.43% | 46 | 1.12% | 50 |
| HLA-B*52:01 | 0.41% | 47 | 2.99% | 32 |
| HLA-C*12:02 | 0.40% | 48 | 3.14% | 30 |
| HLA-B*55:01 | 0.40% | 49 | 0.10% | 103 |
| HLA-C*17:01 | 0.40% | 50 | 0.10% | 102 |
| HLA-A*68:02 | 0.39% | 51 | 0.05% | 114 |
| HLA-C*14:02 | 0.38% | 52 | 4.27% | 23 |
| HLA-A*33:03 | 0.37% | 53 | 8.23% | 12 |
| HLA-A*30:02 | 0.36% | 54 | 0.03% | 126 |
| HLA-B*53:01 | 0.34% | 55 | 0.03% | 122 |
| HLA-B*35:02 | 0.32% | 56 | 0.22% | 85 |
| HLA-B*39:01 | 0.31% | 57 | 1.77% | 44 |
| HLA-B*58:01 | 0.31% | 58 | 6.15% | 15 |
| HLA-C*03:02 | 0.27% | 59 | 5.95% | 17 |
| HLA-A*33:01 | 0.26% | 60 | 0.19% | 90 |
| HLA-A*02:05 | 0.26% | 61 | 0.36% | 75 |
| HLA-B*50:01 | 0.25% | 62 | 0.69% | 66 |
| HLA-B*14:01 | 0.25% | 63 | 0.05% | 115 |
| HLA-C*08:01 | 0.21% | 64 | 8.52% | 10 |
| HLA-B*45:01 | 0.21% | 65 | 0.11% | 99 |
| HLA-B*56:01 | 0.20% | 66 | 0.48% | 73 |
| HLA-C*15:05 | 0.19% | 67 | 0.71% | 64 |
| HLA-B*15:03 | 0.18% | 68 | 0.03% | 128 |
| HLA-B*07:05 | 0.18% | 70 | 0.53% | 71 |
| HLA-B*41:01 | 0.18% | 70 | 0.11% | 100 |
| HLA-A*29:01 | 0.17% | 72 | 0.67% | 67 |
| HLA-C*02:10 | 0.17% | 72 | 0.00% | 183 |
| HLA-B*15:02 | 0.16% | 74 | 3.55% | 25 |
| HLA-A*74:01 | 0.16% | 74 | 0.00% | 166 |
| HLA-A*02:06 | 0.16% | 75 | 5.23% | 20 |
| HLA-B*46:01 | 0.14% | 76 | 10.26% | 6 |
| HLA-B*27:02 | 0.14% | 77 | 0.02% | 135 |
| HLA-B*35:08 | 0.13% | 80 | 0.15% | 97 |
| HLA-A*66:01 | 0.13% | 80 | 0.06% | 111 |
| HLA-B*42:01 | 0.13% | 80 | 0.01% | 141 |
| HLA-A*02:02 | 0.13% | 80 | 0.01% | 154 |
| HLA-B*15:10 | 0.11% | 82 | 0.01% | 146 |
| HLA-B*15:17 | 0.11% | 83 | 0.20% | 88 |
| HLA-B*13:01 | 0.11% | 84 | 5.01% | 21 |
| HLA-A*02:07 | 0.10% | 86 | 8.42% | 11 |
| HLA-B*57:03 | 0.10% | 86 | 0.01% | 155 |
| HLA-C*16:02 | 0.10% | 87 | 0.20% | 89 |
| HLA-B*41:02 | 0.09% | 88 | 0.02% | 131 |
| HLA-A*02:03 | 0.08% | 89 | 3.45% | 26 |
| HLA-B*44:05 | 0.08% | 91 | 0.01% | 148 |
| HLA-A*34:02 | 0.08% | 91 | 0.00% | 181 |
| HLA-B*38:02 | 0.08% | 92 | 2.59% | 36 |
| HLA-A*03:02 | 0.08% | 93 | 0.22% | 84 |
| HLA-B*15:16 | 0.07% | 94 | 0.00% | 199 |
| HLA-A*24:03 | 0.07% | 95 | 0.15% | 96 |
| HLA-C*04:03 | 0.06% | 97 | 1.01% | 53 |
| HLA-A*30:04 | 0.06% | 97 | 0.08% | 108 |
| HLA-B*15:18 | 0.06% | 98 | 1.37% | 47 |
| HLA-B*47:01 | 0.05% | 99 | 0.02% | 134 |
| HLA-B*40:06 | 0.05% | 100 | 3.23% | 29 |
| HLA-B*48:01 | 0.05% | 101 | 2.47% | 38 |
| HLA-A*24:07 | 0.05% | 102 | 0.22% | 87 |
| HLA-B*54:01 | 0.04% | 104 | 3.13% | 31 |
| HLA-B*15:25 | 0.04% | 104 | 0.56% | 70 |
| HLA-B*35:05 | 0.04% | 106 | 0.27% | 80 |
| HLA-B*81:01 | 0.04% | 106 | 0.00% | 159 |
| HLA-A*11:02 | 0.04% | 108 | 1.69% | 45 |
| HLA-B*39:05 | 0.04% | 108 | 0.17% | 93 |
| HLA-C*16:04 | 0.04% | 109 | 0.08% | 107 |
| HLA-A*69:01 | 0.03% | 110 | 0.13% | 98 |
| HLA-B*27:04 | 0.03% | 112 | 0.91% | 54 |
| HLA-C*07:06 | 0.03% | 112 | 0.80% | 59 |
| HLA-B*18:03 | 0.03% | 112 | 0.00% | 179 |
| HLA-B*55:02 | 0.03% | 114 | 2.47% | 37 |
| HLA-B*15:12 | 0.03% | 115 | 0.23% | 83 |
| HLA-B*27:07 | 0.03% | 117 | 0.15% | 95 |
| HLA-A*02:11 | 0.03% | 117 | 0.02% | 138 |
| HLA-B*51:02 | 0.02% | 119 | 1.05% | 51 |
| HLA-A*34:01 | 0.02% | 119 | 0.04% | 118 |
| HLA-B*42:02 | 0.02% | 119 | 0.00% | 162 |
| HLA-C*08:03 | 0.02% | 122 | 0.77% | 60 |
| HLA-B*51:08 | 0.02% | 122 | 0.04% | 119 |
| HLA-B*39:10 | 0.02% | 122 | 0.00% | 192 |
| HLA-C*14:03 | 0.02% | 126 | 1.03% | 52 |
| HLA-A*02:17 | 0.02% | 126 | 0.01% | 156 |
| HLA-B*57:02 | 0.02% | 126 | 0.00% | 168 |
| HLA-A*26:08 | 0.02% | 126 | 0.00% | 176 |
| HLA-B*51:07 | 0.02% | 129 | 0.03% | 124 |
| HLA-B*27:03 | 0.02% | 129 | 0.01% | 147 |
| HLA-B*51:09 | 0.02% | 129 | 0.00% | 166 |
| HLA-B*15:07 | 0.01% | 132 | 0.32% | 77 |
| HLA-B*39:24 | 0.01% | 132 | 0.01% | 143 |
| HLA-B*27:06 | 0.01% | 134 | 0.05% | 112 |
| HLA-B*78:01 | 0.01% | 134 | 0.00% | 199 |
| HLA-B*15:11 | 0.01% | 139 | 1.85% | 43 |
| HLA-B*56:04 | 0.01% | 139 | 0.08% | 106 |
| HLA-A*24:10 | 0.01% | 139 | 0.07% | 109 |
| HLA-B*15:35 | 0.01% | 139 | 0.03% | 129 |
| HLA-A*01:03 | 0.01% | 139 | 0.01% | 140 |
| HLA-B*73:01 | 0.01% | 139 | 0.01% | 142 |
| HLA-C*07:27 | 0.01% | 139 | 0.00% | 161 |
| HLA-A*03:05 | 0.01% | 139 | 0.00% | 199 |
| HLA-A*24:20 | 0.01% | 145 | 0.26% | 81 |
| HLA-B*15:13 | 0.01% | 145 | 0.05% | 113 |
| HLA-B*15:21 | 0.01% | 145 | 0.03% | 124 |
| HLA-C*15:09 | 0.01% | 145 | 0.00% | 192 |
| HLA-B*51:05 | 0.01% | 145 | 0.00% | 206 |
| HLA-C*01:03 | 0.01% | 154 | 0.63% | 68 |
| HLA-B*15:05 | 0.01% | 154 | 0.18% | 91 |
| HLA-B*59:01 | 0.01% | 154 | 0.10% | 104 |
| HLA-A*74:02 | 0.01% | 154 | 0.04% | 120 |
| HLA-C*15:04 | 0.01% | 154 | 0.04% | 121 |
| HLA-B*15:08 | 0.01% | 154 | 0.02% | 137 |
| HLA-A*11:04 | 0.01% | 154 | 0.01% | 152 |
| HLA-A*74:03 | 0.01% | 154 | 0.00% | 163 |
| HLA-A*02:20 | 0.01% | 154 | 0.00% | 164 |
| HLA-B*15:09 | 0.01% | 154 | 0.00% | 173 |
| HLA-B*56:09 | 0.01% | 154 | 0.00% | 192 |
| HLA-B*40:49 | 0.01% | 154 | 0.00% | 199 |
| HLA-A*02:10 | 0.00% | 166 | 0.35% | 76 |
| HLA-A*11:03 | 0.00% | 166 | 0.10% | 101 |
| HLA-A*26:02 | 0.00% | 166 | 0.01% | 139 |
| HLA-B*07:10 | 0.00% | 166 | 0.01% | 151 |
| HLA-C*15:06 | 0.00% | 166 | 0.00% | 166 |
| HLA-B*35:04 | 0.00% | 166 | 0.00% | 176 |
| HLA-A*31:06 | 0.00% | 166 | 0.00% | 183 |
| HLA-B*52:11 | 0.00% | 166 | 0.00% | 188 |
| HLA-A*11:12 | 0.00% | 166 | 0.00% | 188 |
| HLA-C*03:07 | 0.00% | 166 | 0.00% | 192 |
| HLA-B*15:30 | 0.00% | 166 | 0.00% | 199 |
| HLA-A*03:20 | 0.00% | 166 | 0.00% | 206 |
| HLA-B*67:01 | 0.00% | 190 | 0.72% | 62 |
| HLA-B*40:03 | 0.00% | 190 | 0.22% | 86 |
| HLA-B*48:03 | 0.00% | 190 | 0.16% | 94 |
| HLA-B*15:58 | 0.00% | 190 | 0.09% | 105 |
| HLA-B*55:04 | 0.00% | 190 | 0.05% | 116 |
| HLA-B*07:06 | 0.00% | 190 | 0.05% | 117 |
| HLA-B*39:09 | 0.00% | 190 | 0.03% | 125 |
| HLA-C*04:06 | 0.00% | 190 | 0.03% | 127 |
| HLA-C*07:18 | 0.00% | 190 | 0.03% | 130 |
| HLA-A*26:03 | 0.00% | 190 | 0.02% | 132 |
| HLA-C*17:03 | 0.00% | 190 | 0.02% | 133 |
| HLA-A*02:48 | 0.00% | 190 | 0.01% | 144 |
| HLA-B*51:06 | 0.00% | 190 | 0.01% | 145 |
| HLA-A*26:20 | 0.00% | 190 | 0.01% | 149 |
| HLA-A*68:24 | 0.00% | 190 | 0.01% | 150 |
| HLA-B*39:31 | 0.00% | 190 | 0.00% | 159 |
| HLA-C*12:05 | 0.00% | 190 | 0.00% | 159 |
| HLA-A*29:10 | 0.00% | 190 | 0.00% | 169 |
| HLA-B*27:14 | 0.00% | 190 | 0.00% | 170 |
| HLA-B*51:21 | 0.00% | 190 | 0.00% | 173 |
| HLA-C*03:21 | 0.00% | 190 | 0.00% | 173 |
| HLA-C*15:17 | 0.00% | 190 | 0.00% | 173 |
| HLA-A*02:08 | 0.00% | 190 | 0.00% | 177 |
| HLA-C*01:17 | 0.00% | 190 | 0.00% | 178 |
| HLA-B*35:30 | 0.00% | 190 | 0.00% | 181 |
| HLA-C*06:06 | 0.00% | 190 | 0.00% | 183 |
| HLA-A*24:17 | 0.00% | 190 | 0.00% | 185 |
| HLA-C*03:43 | 0.00% | 190 | 0.00% | 188 |
| HLA-C*12:04 | 0.00% | 190 | 0.00% | 188 |
| HLA-A*26:14 | 0.00% | 190 | 0.00% | 192 |
| HLA-B*13:38 | 0.00% | 190 | 0.00% | 199 |
| HLA-A*02:36 | 0.00% | 190 | 0.00% | 199 |
| HLA-B*15:15 | 0.00% | 190 | 0.00% | 199 |
| HLA-A*02:24 | 0.00% | 190 | 0.00% | 199 |
| HLA-B*35:29 | 0.00% | 190 | 0.00% | 206 |
| HLA-B*35:28 | 0.00% | 190 | 0.00% | 206 |
